Oxford, a city in central southern England, revolves around its prestigious university, established in the 12th century. The architecture of its 38 colleges in the city’s medieval center led poet Matthew Arnold to nickname it the 'City of Dreaming Spires'. University College and Magdalen College are off the High Street, which runs from Carfax Tower (with city views) to the Botanic Garden on the River Cherwell. 

Oxford is home to many museums, galleries, and collections, most of which are free of admission charges and are major tourist attractions. The majority are departments of the University of Oxford. The first of these to be established was the Ashmolean Museum, the world's first university museum, and the oldest museum in the UK. Its first building was erected in 1678–1683 to house a cabinet of curiosities given to the University of Oxford in 1677. The museum reopened in 2009 after a major redevelopment. It holds significant collections of art and archaeology, including works by Michelangelo, Leonardo da Vinci, Turner, and Picasso, as well as treasures such as the Scorpion Macehead, the Parian Marble and the Alfred Jewel. It also contains "The Messiah", a pristine Stradivarius violin, regarded by some as one of the finest examples in existence.

The University Museum of Natural History holds the university's zoological, entomological and geological specimens. It is housed in a large neo-Gothic building on Parks Road, in the university's Science Area. Among its collection are the skeletons of a Tyrannosaurus rex and Triceratops, and the most complete remains of a dodo found anywhere in the world. It also hosts the Simonyi Professorship of the Public Understanding of Science, currently held by Marcus du Sautoy. Adjoining the Museum of Natural History is the Pitt Rivers Museum, founded in 1884, which displays the university's archaeological and anthropological collections, currently holding over 500,000 items. It recently built a new research annexe; its staff have been involved with the teaching of anthropology at Oxford since its foundation, when as part of his donation General Augustus Pitt Rivers stipulated that the university establish a lectureship in anthropology.

The Museum of the History of Science is housed on Broad Street in the world's oldest-surviving purpose-built museum building. It contains 15,000 artefacts, from antiquity to the 20th century, representing almost all aspects of the history of science. In the university's Faculty of Music on St Aldate's is the Bate Collection of Musical Instruments, a collection mostly of instruments from Western classical music, from the medieval period onwards. Christ Church Picture Gallery holds a collection of over 200 old master paintings. The university also has an archive at the Oxford University Press Museum.Other museums and galleries in Oxford include Modern Art Oxford, the Museum of Oxford, the Oxford Castle, Science Oxford and The Story Museum.

Art
Art galleries in Oxford include the Ashmolean Museum, the Christ Church Picture Gallery, and Modern Art Oxford. William Turner (aka "Turner of Oxford", 1789–1862), was a watercolourist who painted landscapes in the Oxford area. The Oxford Art Society was established in 1891. The later watercolourist and draughtsman Ken Messer (1931–2018) has been dubbed "The Oxford Artist" by some, with his architectural paintings around the city. In 2018, The Oxford Art Book featured many contemporary local artists and their depictions of Oxford scenes. The annual Oxfordshire Artweeks is well-represented by artists in Oxford itself.

Music
Holywell Music Room is said to be the oldest purpose-built music room in Europe, and hence Britain's first concert hall. Tradition has it that George Frideric Handel performed there, though there is little evidence. Joseph Haydn was awarded an honorary doctorate by Oxford University in 1791, an event commemorated by three concerts of his music at the Sheldonian Theatre, directed by the composer and from which his Symphony No. 92 earned the nickname of the "Oxford" Symphony. Victorian composer Sir John Stainer was organist at Magdalen College and later Professor of Music at the university, and is buried in Holywell Cemetery.

Oxford, and its surrounding towns and villages, have produced many successful bands and musicians in the field of popular music. The most notable Oxford act is Radiohead, who all met at nearby Abingdon School, though other well known local bands include Supergrass, Ride, Mr Big, Swervedriver, Lab 4, Talulah Gosh, the Candyskins, Medal, the Egg, Unbelievable Truth, Hurricane No. 1, Crackout, Goldrush and more recently, South Arcade, Young Knives, Foals, Glass Animals, Dive Dive and Stornoway. These and many other bands from over 30 years of the Oxford music scene's history feature in the documentary film Anyone Can Play Guitar?. In 1997, Oxford played host to Radio 1's Sound City, with acts such as Travis, Bentley Rhythm Ace, Embrace, Spiritualized and DJ Shadow playing in various venues around the city including Oxford Brookes University. It is also home to several brass bands, notably the City of Oxford Silver Band, founded in 1887.